Yet Another Rabbit Hole

adventures in co-curiosity

Trent Leslie · Bioinformatics engineer building AI agents for biological data

Work up top. Rabbit holes all the way down.

the work

Professional work, hosted elsewhere and linked out.

Expert in the Loop

external

A platform for putting human experts in the loop on AI output: review LLM-suggested matches and mappings, build calibrated ground truth, and measure inter-rater reliability. The work app the others below feed into.

view on expertintheloop.io read the story · soon

PGSC Explorer

external

A Streamlit explorer over the Polygenic Score Catalog: browse scores, traits, and provenance without wrangling the raw files.

Biomapper UI

external

The review-and-linking interface over BioMapper2: run entity-mapping campaigns and curate the matches by hand.

BioMapper2 API

external

A FastAPI service that maps biological entities across the namespaces that refuse to agree (HMDB, UniProt, ChEBI), without pretending the mapping is clean. Browsable at /api/v1/docs.

Knowledge Graph Chatbot

external

Ask a biomedical knowledge graph questions in plain language and get answers traced back through multi-omics relationships. A React front end over a FastAPI backend (KRAKEN).

Agent benchmarking

coming soon

Measuring what AI agents actually do on bio tasks (AstaBench, BiomniBench) instead of trusting the demo reel.

try it live · soon read the story · soon

the rabbit holes

Backyard sensing

Real signals from around Dyes Inlet: a BirdWeather station in my yard, plus the nearest NOAA tide gauge. No curation.

Live from PUC-2078 · Erlands Point

Full station on BirdWeather

BirdWeather — Erlands Point

live

A BirdNET station in my backyard (PUC-2078) listening to Dyes Inlet. Live detections, no curation — whatever actually showed up.

try it live read the story · soon

Tide Manifold

live

The moon sets the biggest tides. Here's the local gauge in 3D, plus the winter day the moon can't explain.

try it live read the story · soon

PNW bird cam

coming soon

The Pacific Northwest bird cam, between homes at the moment. The live feed comes back soon, but the channel already has a back catalog worth a scroll.

try it live · soon read the story

Aerobiome sensing

coming soon

Sampling what's actually floating in the backyard air — the part of the microbiome nobody photographs.

try it live · soon read the story · soon

Home lab · the “AI runs my life” meta

The vault, the agents, and the hardware tiers that let one person run all of this.

Internet weather

live

A Raspberry Pi 5 (lamppost) speed-tests two uplinks in parallel, Astound on one NIC and T-Mobile 5G on the other, to settle which ISP actually delivers. A month of data said Astound, once a new coax fixed it: ~940 Mbps at ~12ms.

The vault + agent system

coming soon

The Obsidian vault and the agents that run my life out of it — the 'AI actually accomplishes all of this' thesis, instrumented.

try it live · soon read the story · soon

Home-server tiers

coming soon

The actual hardware stack — from the Linode that serves this page down to the boxes in the closet — and why each tier exists.

try it live · soon read the story · soon